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When the painkillers become the problem

Medication overuse headache is one of the most common reasons a headache disorder becomes daily, and one of the most commonly missed. Here is how it happens, how it is recognised, and what getting out of it actually involves.

5 min readBy The Erin Health teamClinically reviewed by Rosie Scott, Founder, Erin Health

There is a particular kind of stuck that people with headache disorders know well. The attacks used to come now and then. Now the head is never quite clear. Something takes the edge off, so it gets taken more often, and the days without it start to feel worse than they used to. Nothing about that pattern is careless or weak. It is what a sensible person does when their head hurts and they have a life to get on with.

It is also, for a large number of people, the mechanism that turned an episodic headache disorder into a daily one.

What medication overuse headache is

Medication overuse headache, usually shortened to MOH, is a headache that develops in someone who already has a headache disorder, as a consequence of taking acute headache medication regularly over months. The International Classification of Headache Disorders, third edition, defines it as headache occurring on 15 or more days a month in a person with a pre-existing primary headache, developing as a consequence of regular overuse of acute treatment for more than three months.

The thresholds differ by drug class, and this is the part that surprises people:

  • Triptans, ergots, opioids and combination analgesics: 10 or more days a month is enough
  • Simple analgesics such as paracetamol, aspirin and other anti-inflammatories: 15 or more days a month

Ten days a month is two or three days a week. Plenty of people cross that line without ever taking more than the packet says on any single day. The dose is not the issue. The frequency is.

Why it is missed so often

Three reasons, and they compound.

The first is that the pattern is invisible without a record. Almost nobody can accurately reconstruct how many days in the last month they took something. Recall skews low, consistently, and a ten-minute appointment does not leave room to work it out.

The second is that the medication genuinely still works, at least for a few hours, on the day it is taken. When something helps, it does not feel like the culprit. The relationship is only visible over weeks.

The third is that the underlying disorder is still there. MOH sits on top of migraine, or tension-type headache, or whatever came first. Treating one and ignoring the other does not work, which is why "just stop the tablets" is such poor advice on its own.

What getting out of it involves

The evidence-based route out has three parts, and they run at the same time rather than in sequence.

  1. Withdrawing the overused medication. How this is done depends on the drug. Some classes can be stopped abruptly, others need a taper, and opioids in particular need clinical supervision. This is a conversation to have with a prescriber, not a decision to make alone on a Sunday night.
  2. Starting or optimising a preventive. Withdrawal without prevention is why so many attempts fail. A preventive gives the underlying disorder something to work against while the acute treatment is being pulled back.
  3. Planning for the withdrawal period. Symptoms typically get worse before they get better, often for one to two weeks, sometimes longer. Knowing that in advance is the difference between riding it out and concluding after four days that it has not worked.

Recovery rates are good when all three happen together. They are poor when only the first one does, which is worth saying plainly to anyone who has tried before and felt like they failed at it. A withdrawal attempt without a preventive in place was never a fair test.

What to bring to the appointment

If you suspect this pattern in yourself, the single most useful thing you can do before seeing anyone is to count. Not estimate, count. For the last four weeks, or from today forward if you have no record:

  • Which days you had any head pain at all
  • Which days you took anything for it, including over the counter medicines and anything containing codeine or caffeine
  • What you took and how many doses

A clinician looking at that list can reach a diagnosis in a couple of minutes that would otherwise take two or three appointments to circle. It also moves the conversation away from how bad the pain feels, which is hard to convey, and towards a pattern, which is not.

This is the whole reason Erin's diary exists in the shape it does. Attack days and treatment days are recorded separately, because the gap between the two is where this diagnosis lives.

The uncomfortable part

There is a real tension here. People are told to treat attacks early, because treating a migraine early works far better than treating it late. They are also told not to treat too often. Both are true, and the resolution is not a rule of thumb, it is prevention. If attacks are frequent enough that early treatment tips you over ten days a month, the honest answer is that acute treatment alone is not the right plan, and it never was.

That is a conversation worth having before the counting turns into a problem, rather than after.


General information, not personal medical advice. Do not change how you take prescribed medication without speaking to a clinician first.

Filed under

  • medication
  • chronic migraine
  • treatment
  • diagnosis
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